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KMID : 0369820150450010065
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Jorunal of Korean Pharmaceutical Sciences
2015 Volume.45 No. 1 p.65 ~ p.71
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Synthesis, analgesic and anti-inflammatory activities of novel mannich bases of benzimidazoles
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Kumar Neeraj
Sharma C. S.
Ranawat M. S.
Singh H. P.
Chauhan L. S.
Dashora N.
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Abstract
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A series of novel mannich bases of 2-substituted benzimidazoles was synthesized by the reaction of 2-substituted benzimidazoles with corresponding aldehyde and acetophenones. The structures of all synthesized compounds were confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR and LCMS. The compounds were evaluated for in vivo analgesic and in vivo anti-inflammatory activities by a tail flick method and carrageenan-induced rat paw edema test respectively. Among all the compounds synthesized, compound A1 and B3 exhibited significant analgesic and anti-inflammatory activities. Acute ulcerogenicity studies showed that compound A1 and B3 were devoid of gastrointestinal toxicities.
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KEYWORD
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Benzimidazole, Mannich base, Anti-inflammatory, Analgesic, Ulcerogenicity
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